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Brain Behavior and Immunity

ISSN 0889-1591

2 papers in the library · 112 citations · publishing 2022-2023

Papers

Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study

Brain Behavior and Immunity September 7, 2023 Natasha L. Mason, Attila Szabo, Kim P. C. Kuypers et al. 83 citations

A single dose of psilocybin (0.17 mg/kg) in 60 healthy participants immediately reduced the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α), while interleukin-1β, interleukin-6 (IL-6), and C-reactive protein (CRP) were unchanged. Seven days later, TNF-α returned to baseline, but IL-6 and CRP were persistently reduced. Greater reductions in IL-6 and CRP at seven days correlated with more positive mood and social effects. Acute TNF-α reductions linked to lower hippocampal glutamate. Psilocybin did not significantly alter the stress response to a psychosocial stressor. The findings suggest psilocybin has persisting anti-inflammatory effects that may relate to its therapeutic benefits.

DOI: 10.1016/j.bbi.2023.09.004 (opens in new tab) Psilocybin Placebo Immune system Internal medicine +6

Smartphone mindfulness meditation training reduces Pro-inflammatory gene expression in stressed adults: A randomized controlled trial

Brain Behavior and Immunity April 12, 2022 Janine M. Dutcher, Steve W Cole, Adrian Williams et al. 29 citations

A 30-day smartphone-based mindfulness meditation training program reduced activity of the pro-inflammatory NF-κB transcription control pathway in stressed customer service workers, compared to a problem-solving control program. Both interventions lowered stress levels equally, but only mindfulness training produced a specific immunoregulatory benefit, suggesting it may be a particularly effective method for improving immune cell gene expression in stressful work environments.

DOI: 10.1016/j.bbi.2022.04.003 (opens in new tab) Mindfulness meditation Randomized controlled trial Psychological intervention Mindfulness-based stress reduction +3