Psychedelic-assisted therapy clinical trials conducted over the past decade have prompted increased interest in the use of psychedelics to treat nonphysical suffering, which can include significant spiritual and existential distress at the end of life. The authors explore the role of psychedelics in helping to address patients' spiritual and existential suffering from a medical, ethical, and...
Given the historical association of psychedelics as “recreational” mind-altering compounds within countercultures of the 1960s and 1970s, their current introduction into several aspects of medical practice is a surprise to many.
Preliminary evidence suggests that psychedelic-assisted therapy-the enhancement of psychotherapy with psychedelics such as 3,4-methylenedioxymethamphet-amine (MDMA) and psilocybin-may be efficacious for depression, posttraumatic stress disorder, substance use disorders, and other conditions. Therapeutic psychedelic research is advancing steadily, with psilocybin, MDMA, and lysergic acid...