ISSN 0009-9236
3 papers in the library · publishing 2001-2016
Clinical Pharmacology & Therapeutics February 1, 2016 M Rowland
Poor pharmacokinetics (PK) can seriously limit clinical utility. Knowing early whether a new compound is likely to have the desired PK profile at therapeutic doses is therefore important. One approach, microdosing,has shown high success with small molecular weight compounds,despite early skepticism. Vlaminget al.report the first, and successful, clinical application of a microdose of a...
Clinical Pharmacology & Therapeutics September 1, 2015 M Roth‐Cline, RM Nelson
Microdosing studies in children are used to obtain pharmacokinetic information, to study the ontogeny of metabolic enzymes, or to study drug disposition.
Clinical Pharmacology & Therapeutics November 1, 2001 Harald Ihmsen, Gerd Geisslinger, Jürgen Schüttler
ObjectiveWe investigated the pharmacokinetics of ketamine with special regard to enantiomer‐specific differences.MethodsTen healthy young male volunteers (mean age, 28 ± 4 years; mean weight, 79 ± 11 kg) received racemic ketamine and S(+)‐ketamine in a randomized double‐blind crossover study. Drugs were administered by a computer‐controlled device. Two infusion cycles with linearly increasing...