Better Biomarkers, Faster Drugs, Stronger Models: Progress Towards Precision Psychiatry.
Missouri medicine 2023 Joshua S. Siegel, Craig S Pearson, Eric J Lenze 592 citations
The 21st century has brought novel therapies and new therapeutic targets for major depressive disorder (MDD). Until recently all antidepressant medications targeted monoamines-serotonin, norepinephrine, and dopamine- and their regulatory systems. But growing evidence has suggested that individuals who fail to respond to a monoaminergic treatment are likely to fail to respond to other...