The Pharmacological and Ultra High Dilution Esketamine (12cH) Prevent Morphine-Conditioned Place Preference and Reprogram Reward-Related Plasticity in Opioid-Exposed Offspring
International Journal of High Dilution Research May 7, 2026 Murilo Barboza Fontoura, Jessica Leandra Oliveira da Rosa, Paola Brivio et al.
Introduction: Intergenerational opioid exposure induces persistent maladaptive plasticity in the mesolimbic reward circuitry, increasing vulnerability to addiction. Transcriptional adaptations, including CREB-dependent signaling and neurotrophic dysregulation, contribute to relapse risk and may reflect epigenetically mediated alterations transmitted across generations. While pharmacological...