LC–MS/MS-Based Quantitative Investigation of the Exposure Characteristics of Psilocin, the Active Metabolite of Psilocybin, in Rats
International Journal of Pharmacology October 9, 2026 Jingtao Wang, Bohong Zheng, Chuyao Yang et al.
Background: Psilocybin has shown promising antidepressant effects; however, pharmacokinetic data on psilocybin and the associated active metabolite, psilocin, remain limited. Thus, this study aimed to develop and validate a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for quantifying psilocin and to investigate the associated pharmacokinetics, tissue distribution, excretory...