Anesthesia and analgesia

Inhibition by ketamine of muscarinic acetylcholine receptor function.

Anesthesia and analgesia July 1, 1995 M E Durieux

Although ketamine's primary site of action appears to be the phencyclidine receptor on the N-methyl-D-aspartate (NMDA) receptor complex, additional activity on opiate and quisqualate receptors is suggested. Some phencyclidines have been shown to interact with muscarinic receptors, but this has not been determined for ketamine. We studied the interaction between ketamine and the m1 muscarinic...