Mind over microglia: using mindfulness-based interventions to target stress-induced neuroinflammatory mediators to improve behavioral symptoms
NeuroImmune Pharmacology and Therapeutics October 31, 2026 Elizaveta Valovatsky, Zeel Patel, Pooja Jain
Abstract Chronic psychosocial stress is associated with dysregulation of neuroendocrine and immune pathways that may contribute to symptom exacerbation in individuals with psychotic disorders. Repeated activation of the hypothalamic–pituitary–adrenal (HPA) axis and sympathetic systems can alter glucocorticoid signaling, inflammatory mediators, blood–brain barrier function, and neuroimmune...