Glia

GLT-1 expression and Glu uptake in rat cerebral cortex are increased by phencyclidine.

Glia September 2008 Giorgia Fattorini, Marcello Melone, Luca Bragina et al.

Using western blottings, microdialysis, and functional assays we tested the hypothesis that phencyclidine (PCP) modifies the expression and function of glutamate (Glu) transporters in the rat frontal cortex. Western blotting studies revealed that administration of PCP (10 mg/kg/day; 7 days) increased significantly the expression of the astrocytic Glu transporter GLT-1/EAAT2. Functional studies...