BMB reports

Autistic-like social deficits in hippocampal MeCP2 knockdown rat models are rescued by ketamine.

BMB reports May 2022 Miyeon Choi, Seung Yeon Ko, Jee Young Seo et al.

Autism or autism spectrum disorder (ASD) is a behavioral syndrome characterized by persistent deficits in social interaction, and repetitive patterns of behavior, interests, or activities. The gene encoding Methyl-CpG binding protein 2 (MeCP2) is one of a few exceptional genes of established causal effect in ASD. Although genetically engineered mice studies may shed light on how MeCP2 loss...