Carbon 11 labeling of the psychoactive drug o-methyl-bufotenine and its distribution in the animal organism.
European journal of nuclear medicine April 1, 1978 G Berger, M Mazière, C Marazano et al. 20 citations
O-methyl-bufotenine, a serotonin derivative, can be produced in high purity and quantity using a novel methylation method, yielding several tens of millicuries in just 50 minutes. This compound exhibits a specific radioactivity of 50 to 100 mCi/mumol. In distribution studies involving mice and rabbits, significant accumulation was observed in the brain (notably), kidneys, lungs, and liver. Its rapid kinetics, with a 20-minute half-life, makes O-methyl-[11C]bufotenine a promising tool for in vivo detection of serotonin receptors related to mental health conditions.