The treatment for patients with disorders of consciousness challenges researchers and clinicians. The stimulation of the left dorsolateral prefrontal cortex with transcranial direct current stimulation (tDCS) may enhance behavioral responsiveness of a subset of patients in a minimally conscious state, while having limited effects in unresponsive patients. However, heterogeneity in responses...
While anecdotal evidence suggests that select 5-hydroxytryptamine 2A (5-HT2A) receptor ligands, including psilocybin, may have long-lasting therapeutic effects after limited dosing in headache disorders, controlled investigations are lacking. In an exploratory double-blind, placebo-controlled, cross-over study, adults with migraine received oral placebo and psilocybin (0.143 mg/kg) in 2 test...