Serotonin-degradative pathways in the toad (Bufo bufo japonicus) brain: clues to the pharmacological analysis of human psychiatric disorders.
Comparative biochemistry and physiology. Pharmacology, toxicology and endocrinology February 1, 1994 N Takeda 9 citations
High levels of bufotenine (BUTN) and its precursor, N-methylserotonin, accumulate mainly in the brains of toads, particularly in the hindbrain regions. In a study involving urine samples from infant autistic patients, BUTN was detected, suggesting it could serve as a potential diagnostic marker for autism. The analysis utilized three-dimensional HPLC and indicates that these compounds may offer valuable insights into the neurological underpinnings of psychiatric conditions linked to serotonin methylation, highlighting a fascinating connection between toad biology and human mental health.