Potential Drug Abuse Therapeutics Derived from the Hallucinogenic Natural Product Salvinorin A.
MedChemComm December 1, 2011 Katherine M Prevatt-Smith, Kimberly M Lovell, Denise S Simpson et al. 50 citations
Previous structure-activity relationship studies of salvinorin A have shown that modification of the acetate functionality off the C-2 position to a methoxy methyl or methoxy ethyl ether moiety leads to increased potency at KOP receptors. However, the reason for this increase remains unclear. Here we report our efforts towards the synthesis and evaluation of C-2 constrained analogs of...