Rapid Synthesis of Psychoplastogenic Tropane Alkaloids
JACS Au October 5, 2023 Winston L. Chow, Monica A. Gonzalez, Arabo A. Avanes et al. 7 citations
Tropane alkaloids are an important class of biologically active small molecules characterized by their 8-azabicyclo[3.2.1]octane core. Because of their numerous medicinal applications, microbial biosynthesis and a variety of chemical syntheses have been designed for individual family members. However, current approaches are not amenable to late-stage structural diversification at N8, C3, C6, or...