Medical Journal of Babylon

Amyloid Precursor Protein Immunohistochemical Changes in the Occipital Cerebral Cortex of Newborn Mice Affected by Prenatal Ketamine Exposure

Medical Journal of Babylon May 27, 2026 Mohanad Suhail Najm, Nahidah Ibrahim Hammadi, Anas Hamed Musleh et al.

Background: B-amyloid plaque is a lesion in the brain’s gray matter, imaging studies show significant Ab aggregation in the occipital lobes. This inflammatory reaction causes neuronal impairment and neurotoxicity. Ketamine, an NMDA receptor blocker used in pediatrics, can cause neuronal death or neurodegeneration during embryonic phases, as animal trials have shown. Objectives: The study...