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bioRxiv Preprint Server

160 papers in the library · 452 citations · publishing 2015-2026

Papers

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SLC6A4 binding site and acute prosocial effects of (+/-)-3,4-methylendioxymethamphetamine (MDMA) are evolutionarily conserved in Octopus bimaculoides

bioRxiv Preprint Server April 16, 2018 Eric Edsinger, Gül Dölen 1 citation preprint

Human and octopus lineages are separated by over 500 million years of evolution, and show divergent anatomical patterns of brain organization. Moreover, while humans exhibit highly complex social behaviors, octopuses are thought to be largely asocial and solitary. Despite these differences, growing evidence suggests that ancient neurotransmitter systems are shared across vertebrate and...

The biosynthetic origin of psychoactive kavalactones in kava

bioRxiv Preprint Server April 4, 2018 Tomáš Pluskal, Michael P. Torrens-Spence, Timothy R. Fallon et al. 3 citations preprint

For millennia, humans have used plants for medicinal purposes. However, our limited understanding of plant biochemistry hinders the translation of such ancient wisdom into modern pharmaceuticals1. Kava (Piper methysticum) is a medicinal plant native to the Polynesian islands with anxiolytic and analgesic properties supported by over 3,000 years of traditional use as well as numerous recent...

The Hallucination Machine: A Deep-Dream VR platform for Studying the Phenomenology of Visual Hallucinations

bioRxiv Preprint Server November 3, 2017 Keisuke Suzuki, Warrick Roseboom, David J. Schwartzman et al. 2 citations preprint

Altered states of consciousness, such as psychotic or pharmacologically-induced hallucinations, provide a unique opportunity to examine the mechanisms underlying conscious perception. However, the phenomenological properties of these states are difficult to isolate experimentally from other, more general physiological and cognitive effects of psychoactive substances or psychopathological...

Rhythms of the Body, Rhythms of the Brain: Respiration, Neural Oscillations, and Embodied Cognition

bioRxiv Preprint Server August 9, 2017 Somogy Varga, Detlef H. Heck 6 citations preprint

In spite of its importance as a life-defining rhythmic movement and its constant rhythmic contraction and relaxation of the body, respiration has not received attention in Embodied Cognition (EC) literature. Our paper aims to show that (1) respiration exerts significant and unexpected bottom-up influence on cognitive processes, and (2) it does so by modulating neural synchronization that...

Locomotor and Reinforcing Effects of Pentedrone, Pentylone and Methylone in Rats

bioRxiv Preprint Server July 21, 2017 Mehrak Javadi-Paydar, Jacques D. Nguyen, Sophia A. Vandewater et al. 7 citations preprint

The broad diversity of synthetic cathinone psychostimulant drugs that are available to users complicates research efforts to provide understanding of health risks. Second generation cathinones pentedrone and pentylone are distinguished from each other by the 3,4-methylenedioxy structural motif (which distinguishes methamphetamine from 3,4-methylenedioxymethamphetamine) and each incorporates the...

Calming Meditation Increases Altruism, Decreases Parochialism

bioRxiv Preprint Server April 10, 2017 Karl Frost 5 citations preprint

It has been proposed that cultivating calm will increase altruism and decrease parochialism, where altruism is defined as self-sacrifice in support of others, regardless of group affiliation or identity, and parochialism is defined as prosocial self-sacrifice restricted to fellow members of a group. Such could be the case with a calming meditation practice. An alternate hypothesis, coming from...

A theory of working memory without consciousness or sustained activity

bioRxiv Preprint Server December 14, 2016 Darinka Trübutschek, Sebastien Marti, Andrés Ojeda et al. 47 citations preprint

Working memory and conscious perception are thought to share similar brain mechanisms, yet recent reports of non-conscious working memory challenge this view. Combining visual masking with magnetoencephalography, we demonstrate the reality of non-conscious working memory and dissect its neural mechanisms. In a spatial delayed-response task, participants reported the location of a subjectively...

A Logical Inquiry of Emotions and Cognition

bioRxiv Preprint Server November 15, 2016 Arturo Tozzi, Colin James, James F Peters 1 citation preprint

Experimental procedures in neuroscience rely on the standpoints that the mind is a functional state of the brain and a clear subdivision among different mental faculties does exist in the cortex. According to cognitive neuroscientists, the term "mind" encompasses just the "cognitive" faculties, such as consciousness, perception, thinking, judgement, memory, leaving apart the "emotional" states....

Coevolutionary Dynamics of Costly Bonding Ritual and Altruism

bioRxiv Preprint Server June 24, 2016 Karl Frost 3 citations preprint

While altruistic behavior and bonding in altruistic pairs or groups of cooperators is observed throughout the animal kingdom, the genetic evolution of such is on an ongoing source of debate, curiosity, and conflict in the behavioral sciences. Many such bonded groups and pairs are observed to take part in costly ritualized movement behavior that is hypothesized to trigger or maintain altruistic...

Can mindfulness meditation alter consciousness? An integrative interpretation

bioRxiv Preprint Server August 13, 2015 Jordi Manuello, Ugo Vercelli, Andrea Nani et al. 1 citation preprint

Mindfulness meditation has been practiced in the East for more than two millennia, but in last years also Western neurscientists drown their attention to it. Mindfulness basically refers to moment to moment awareness. In this review we summarize different hypotheses concerning effects of mindfulness meditation practice and cerebral correlates accounting for these; furthermore we expose some of...