Short-term efficacy and safety of intravenous ketamine for major depressive disorder in adolescents: a systematic review and metaanalysis of randomized and open-label studies
Annals of Middle Eastern Medicine August 15, 2026 Abdulaziz Turki Alqabli, Aisha Abdullah Ateeq Alharbi, Wajan Majed Alahmadi et al.
Background: Adolescent major depressive disorder (MDD) is associated with substantial impairment, suicide risk, and limited response to standard treatments. Intravenous ketamine has rapid antidepressant effects in adults, but pediatric evidence remains limited. This systematic review and meta-analysis evaluated the short-term efficacy and safety of intravenous ketamine for adolescents with MDD,...