Ketamine is the prototypal rapid-acting antidepressant (RAAD) for TRD with approved indication for esketamine-nasal spray (ESK-NS). Distinctly, arketamine (R-KET) demonstrates enhanced antidepressant effects and neuroplasticity changes compared to esketamine, with fewer dissociative side effects and abuse potential. This study focuses on R-ketamine's therapeutic implications, safety, and...
Humans have asked themselves the question "who am I" from ancient times. Vedic, upanishadic and buddhist philosophers have pointed out over millennia the illusive nature of the individual self, and posit either a no-self, or a universal Self. Vedantic scholars also posit the illusory nature of the universe (Maya) and suggest that the only reality is the knower (Brahman), a view resonating with...
Most of the studies examining the impact of cannabis use in first episode psychosis (FEP) have been carried out in samples with adult-onset FEP. Data in persons with early onset psychosis (EOP) is scarce. The aims of the study were: To describe the prevalence of lifetime cannabis use, current use, and daily use in patients with EOP compared to healthy controls. To study the differences in...
This paper discusses the case of Tajuddin, a patient in the mental asylum of Nagpur towards the end of the 19th century. Discussions are based on hospital records and annual reports and relevant literature review of the life and times of Tajuddin. Hospital and associated records indicate that Tajuddin was thought to be suffering from cannabis psychosis. He was released from the British army for...
Suicide and depression are among the most alarming phenomena prevalent throughout the world. Various approaches have tried to explain the intricacies in depression and suicide, as a consequence of faulty psychological adjustment of the individual. Several therapeutic approaches have been developed to strengthen one's coping process, among which cognitive behaviour therapy has shown promising...
Asian Journal of PsychiatryOctober 2018Naren P. Rao, Gopikrishna Deshpande, Kalyani Bangalore Gangadhar et al.
OM chanting is an ancient technique of Indian meditation. OM chanting is associated with an experience of relaxation, changes in autonomic balance and deactivation of limbic brain regions. While functional localization is important, how brain regions interact with each other has been shown to underlie various brain functions. Therefore, in this study, we tested the hypothesis that there is...
Chronic pain is estimated to occur in from 5.5% to 33% of the world's adult population (Gureje et al., 1998). Chronic pain is frequently treated with opiates, which has produced an opiate addiction crisis (Dowell et al., 2016). Several non-pharmacological treatment alternatives can help manage chronic pain. There is moderate evidence that mindfulness-based interventions (MBIs) such as...
Psilocybin, the clinically most researched classic psychedelic has recently been tested for its safety and efficacy in a clinical population of treatment resistant depression. The efficacy of psilocybin in clinical depression previously demonstrated in the elecrophysiologic and neuroimaging findings as also in neuropsychological assessments is further validated by the findings of this...
While there has been a large increase in scientific studies on spirituality, there has been too few of studies of the core of spirituality: spiritual experiences (SE), which often involve altered states of consciousness, reports of anomalous experiences and of consciousness beyond the body. This paper argues that SE, although usually neglected in debates regarding mind-brain relationship (MBR),...
Since spiritual experiences (SE) very often resemble dissociative and psychotic symptoms, there is a risk of misdiagnosis in both directions: labeling a healthy SE as a mental disorder or taking a mental disorder as an SE. There is a scarcity of well-controlled studies on this subject. The paper provides a brief overview of studies on dissociative and psychotic experiences in the non-clinical...
Experiential evidence suggests that the main features of spiritual experience are euphoria, and a feeling of the expansion and unification of consciousness. A way towards understanding this state and how it might arise comes from a consideration of a state in which these features are lacking. Such a state is borderline personality disorder, central to which is a "painful incoherence" that is...