mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
Journal of Molecular Psychiatry September 17, 2013 Jason M. Dwyer, Ashley E. Lepack, Ronald S. Duman 81 citations
A single injection of the experimental compound LY341495, which blocks mGluR2/3 receptors, rapidly and lastingly reversed anhedonia—a core symptom of depression—in rats subjected to chronic unpredictable stress. The effect appeared within one to two days and persisted for at least ten days, a timeline comparable to the rapid antidepressant action of ketamine but without ketamine's side effects and abuse potential. Typical antidepressants require weeks to produce a response. The findings suggest that mGluR2/3 antagonists may offer a safer alternative for fast-acting depression treatment.