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Kamil Hnatyk

2 papers in the library · 42 citations · publishing 2023-2025

Papers

Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review

Antioxidants March 2, 2023 Jan Lazur, Kamil Hnatyk, Katarzyna Kała et al. 42 citations

Depression affects over 322 million people globally, and current treatments based on the monoamine theory have limited efficacy, with about 30% of cases being treatment-resistant. Observational studies suggest that mushroom consumption is associated with lower odds of depression. This review explains the antidepressant activity of edible and medicinal mushrooms through several mechanisms: they provide serotonin precursors, contain psilocybin as a rapid-acting antidepressant, and exhibit anti-neuroinflammatory and antioxidant effects that influence neurotrophin expression, neurogenesis, and the gut–brain axis.

DOI: 10.3390/antiox12030623 (opens in new tab) Antidepressant Traditional medicine Pharmacology

Role of mycelia derived from in vitro cultures of Amanita spp. as a potential source of bioactive compounds with therapeutic potential for the mitigation and management of depressive disorders.

Psychiatria Polska October 31, 2025 Katarzyna Kała, Katarzyna Sułkowska-Ziaja, Joanna Piotrowska et al.

The mycelium of Amanita muscaria and Amanita pantherina, grown in 10 L air-lift bioreactors, contains several bioactive compounds. A. muscaria mycelium had higher levels of lovastatin, ergothioneine, and 5-hydroxy-L-tryptophan than A. pantherina. The presence of muscimol and other previously unstudied substances in cultivated mycelium, compared to fruiting bodies, suggests potential relevance for depression treatment, but further in vitro and clinical research is needed.

DOI: 10.12740/pp/onlinefirst/193251 (opens in new tab) Full text (opens in new tab) Bioelements Indole compounds Muscimol