Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
Science February 16, 2023 Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong et al. 467 citations
Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics. Activation of 5-hydroxytryptamine (serotonin) 2A receptors (5-HT2ARs) is essential for psychedelic-induced cortical plasticity, but it is currently...