Prepulse inhibition of the acoustic startle reflex impairment by 5-HT2A receptor activation in the inferior colliculus is prevented by GABAA receptor blockade in the pedunculopontine tegmental nucleus.
Behavioural Brain Research June 25, 2023 Rodolpho Pereira de Oliveira, Thaís S. Yokoyama, Lucas de Santana Cardoso Thomaz et al. 2 citations
The relationship between serotonin dysfunction and schizophrenia commenced with the discovery of the effects of lysergic acid diethylamide (LSD) that has high affinity for 5-HT2A receptors. Activation of these receptors produces perceptual and behavioural changes such as illusions, visual hallucinations and locomotor hyperactivity. Using prepulse inhibition (PPI) of the acoustic startle, which...
DOI: 10.1016/j.bbr.2023.114436 (opens in new tab)
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Gaba
Inferior colliculus
Pedunculopontine tegmental nucleus
Prepulse inhibition
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