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Holly K. Hamilton

2 papers in the library · 3 citations · publishing 2024-2025

Papers

Editorial: Down the rabbit hole - the psychological and neural mechanisms of psychedelic compounds and their use in treating mental health and medical conditions.

Front Psychiatry June 10, 2024 Leehe Peled-Avron, Jacob S. Aday, Amilia Lydia Kalafateli et al. 2 citations

Psychedelic compounds produce profound alterations in consciousness and perception, and emerging evidence suggests they may be effective treatments for several mental health and medical conditions. This editorial introduces a collection of articles that explore the psychological and neural mechanisms underlying these effects, including how psychedelics modulate brain networks, promote neuroplasticity, and facilitate therapeutic change. The authors argue that understanding these mechanisms is crucial for developing safe and effective psychedelic-assisted therapies. They highlight the need for rigorous research to clarify how these compounds work and to optimize their clinical application.

A meta-analytic analysis of the acute effects of MDMA on empathy and emotion recognition in humans

Scientific Reports November 29, 2025 Leehe Peled-Avron, Jacob S. Aday, Madeline M. Pantoni et al. 1 citation

MDMA enhances emotional empathy but reduces accuracy in recognizing negative facial expressions such as sadness, fear, and anger. No significant effects were found on cognitive empathy or recognition of happy expressions. These findings come from a meta-analysis of studies using the Multifaceted Empathy Test and the Facial Emotion Recognition Task. Understanding these nuanced effects may help optimize therapeutic applications and safety considerations for MDMA-assisted psychotherapy, which is currently under regulatory review for post-traumatic stress disorder.