Sex-dependent effects of psychedelics: review of evidence from rodent models
Frontiers in Psychiatry July 15, 2026 Rafał Marecki, Wiktoria Zaniewska, Adam Hamed et al.
Classic psychedelics, including psilocybin, LSD, DMT, 5-MeO-DMT, mescaline, and phenethylamines such as DOI, exert their core effects through 5-HT2A receptor agonism, inducing widespread neurobiological and behavioral changes relevant to psychiatric research. Emerging evidence suggests that these effects are modulated by sex, yet this dimension remains underrepresented in studies. This review...