Stephan G Anagnostaras

2 papers in the library · publishing 2019-2026

Papers

Dose-effect analysis of 6-APB ("Benzofury") on fear memory, motor behavior, and reward.

Psychopharmacology July 14, 2026 Kyla Whitelock, Kaitlin R Van Alstyne, Liam J Conaboy et al.

6-APB, a recreational drug similar to MDMA, produces effects at very low doses (0.01 and 0.1 mg/kg) in mice, while impairing short-term fear memory and long-term context memory at 5 mg/kg. It also causes modest locomotor sensitization and may produce addiction. Reduced shock reactivity appears due to ataxia rather than analgesia. The behavioral profile broadly resembles MDMA, but amnesic effects emerge at higher doses than MDMA, and there is a larger gap between potential therapeutic doses and doses causing cognitive deficits. These findings suggest 6-APB may not be a low-risk therapeutic alternative to MDMA.

DOI: 10.1007/s00213-026-07123-7 Full text 6-apb Benzofury MDMA Derivative Novel psychoactive substance

MDMA and Pavlovian Fear Memory: Dose‐Effect Analysis

The FASEB Journal April 1, 2019 Madeline M. Pantoni, Stephan G Anagnostaras

Low to moderate doses of MDMA (less than 3 mg/kg), typical of recreational or therapeutic use, may not impair learning and memory as severely as high doses. In mice trained with a Pavlovian fear conditioning paradigm, doses from 0.1 to 8 mg/kg were tested. Immediate memory and long-term contextual and cued memory were assessed one week later. The findings help determine whether low doses are therapeutically viable without adverse cognitive effects.

DOI: 10.1096/fasebj.2019.33.1_supplement.666.6 Full text MDMA Ecstasy Anxiety Context archaeology +10