Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development.
Nature Neuroscience July 1, 2025 Ya'El Courtney, Joshua P Head, Neil Dani et al. 10 citations
The choroid plexus (ChP) regulates cerebrospinal fluid (CSF) composition, providing essential molecular cues for brain development; yet, embryonic ChP secretory mechanisms remain poorly defined. Here we identify apocrine secretion by embryonic ChP epithelial cells as a key regulator of the CSF proteome and neurodevelopment in male and female mice. We demonstrate that the activation of...