Elizabeth D Yimer

A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development.

bioRxiv : the preprint server for biology January 16, 2024 Ya'El Courtney, Joshua P Head, Elizabeth D Yimer et al. 9 citations preprint

We discovered that apocrine secretion by embryonic choroid plexus (ChP) epithelial cells contributes to the cerebrospinal fluid (CSF) proteome and influences brain development in mice. The apocrine response relies on sustained intracellular calcium signaling and calpain-mediated cytoskeletal remodeling. It rapidly alters the embryonic CSF proteome, activating neural progenitors lining the...