MDMA-induced CYP2D6 inhibition: concentration-dependent variability using dextromethorphan as a probe
Drug Metabolism and Personalized Therapy June 16, 2026 Faezeh Ahmadi, Hoda Lavasani, Mohammadhosein Keshvadi et al.
OBJECTIVES: Ecstasy is commonly abused due to entactogenic effects. Although our previous studies on isolated perfused rat model confirmed inhibition of CYP2D6 by MDMA, the time for enzyme recovery was different when mirtazapine and tramadol were used as substrates. Therefore, present study intended to investigate CYP2D6 inhibition by MDMA using dextromethorphan as a well-known probe. Two...