Extrasynaptic δ-GABAA receptors are high-affinity muscimol receptors.
Journal of Neurochemistry April 1, 2019 Ali Y Benkherouf, Kaisa-Riitta Taina, Pratap Meera et al. 26 citations
Muscimol, the major psychoactive ingredient in the mushroom Amanita muscaria, has been regarded as a universal non-selective GABA-site agonist. Deletion of the GABAA receptor (GABAA R) δ subunit in mice (δKO) leads to a drastic reduction in high-affinity muscimol binding in brain sections and to a lower behavioral sensitivity to muscimol than their wild type counterparts. Here, we use forebrain...