Semisynthetic neoclerodanes as kappa opioid receptor probes.
Bioorganic & medicinal chemistry May 1, 2012 Kimberly M Lovell, Tamara Vasiljevik, Juan J Araya et al. 35 citations
Modification of the furan ring of salvinorin A (1), the main active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. Conversion of the furan ring to an aldehyde at the C-12 position (5) has allowed for the synthesis of analogues with new carbon-carbon bonds at that position. Previous methods for forming these bonds, such as...