AMPA receptor modulation in depression: from molecular mechanisms of plasticity to therapeutic translation
Pharmacological Reports June 12, 2026 Wojciech Ziemichód, Natalia Kajka, Klaudia Kister et al.
The glutamatergic system, particularly N-methyl-D-aspartate (NMDA) receptors, has long been a significant focus of research into new strategies for treating depression, and the clinical success of ketamine, an NMDA receptor antagonist, has been a significant breakthrough. In parallel, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, another key component of the...