Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice
Nature Communications May 12, 2022 Radhika Rawat, Elif Tunc-Ozcan, Tammy L. Mcguire et al. 69 citations
Ketamine treatment decreases depressive symptoms within hours, but the mechanisms mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity of adult-born immature granule neurons (ABINs) in the mouse hippocampal dentate gyrus is both necessary and sufficient for the rapid antidepressant effects of ketamine. Ketamine treatment activates ABINs in parallel with...