Ketamine as a therapeutic agent for depression and pain: mechanisms and evidence.
Journal of Neurological Sciences 2022 Subha Subramanian, S. Haroutounian, Ben J Palanca et al. 58 citations
Ketamine is an anesthetic drug which is now used to treat chronic pain conditions and psychiatric disorders, especially depression. It is an N-methyl-D-aspartate (NMDA) receptor antagonist with additional effects on α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, opioid receptors, and monoaminergic...