Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials
Pharmacological Reports April 16, 2020 J. Kryst, Paweł Kawalec, Alicja Mikrut Mitoraj et al. 157 citations
Due to unmet clinical needs for efficient drugs with a rapid onset of antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different subgroups of patients with major depression and establish whether repeated ketamine administration could be a viable strategy to maintain treatment gains. Electronic databases (Medline via PubMed, Embase, Cochrane Library, Trip...