Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Neuropsychopharmacology February 24, 2020 Chadi G. Abdallah, Lynnette A. Averill, Ralitza Gueorguieva et al. 181 citations
Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1). To test this hypothesis, depressed patients were pretreated with rapamycin, an mTORC1 inhibitor, prior to receiving ketamine. Twenty patients suffering a major depressive episode were randomized...