Taro Kato

2 papers in the library · publishing 2019-2023

Papers

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Role of mTOR1 signaling in the antidepressant effects of ketamine and the potential of mTORC1 activators as novel antidepressants.

Neuropharmacology February 1, 2023 Taro Kato

Conventional antidepressant medications act on monoaminergic systems and have important limitations, including a therapeutic delay of weeks to months and low rates of efficacy. Recently, clinical findings have indicated that ketamine, a dissociative anesthetic that blocks N-methyl-d-aspartate receptor channel activity, causes rapid and long-lasting antidepressant effects. Although the exact...

DOI: 10.1016/j.neuropharm.2022.109325 Full text Ketamine Major depressive disorder Antidepressants Glutamatergic signaling +1

Rapastinel, a novel glutamatergic agent with ketamine-like antidepressant actions: Convergent mechanisms.

Pharmacology, Biochemistry, and Behavior November 13, 2019 Taro Kato, Ronald S. Duman

Conventional antidepressant medications, which act on monoaminergic systems, have significant limitations, including a time lag of weeks to months and low rates of therapeutic efficacy. Recently, clinical findings demonstrate that ketamine, a dissociative anesthetic that blocks N-methyl-d-aspartate (NMDA) receptor channel activity, causes rapid (within hours) and long-lasting (7 to 10 days)...

DOI: 10.1016/j.pbb.2019.172827