Mechanisms of Ketamine and its Metabolites as Antidepressants
Biochemical Pharmacology December 1, 2021 E. Hess, L. Riggs, Michael Michaelides et al. 167 citations
Treating major depression is a medical need that remains unmet by monoaminergic therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in the treatment of depression was the discovery that the anesthetic (R,S)-ketamine (ketamine), when administered at sub-anesthetic doses, elicits rapid (sometimes within hours) antidepressant effects in humans that are otherwise...