Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
Nature October 18, 2023 Shuangshuang Ma, Min Chen, Yihao Jiang et al. 202 citations
The discrepancy between the short half-life of ketamine and its long-lasting effects is due to ketamine being trapped in NMDA receptors, and its release depends on neural activity in the lateral habenula. Ketamine, an N -methyl- d -aspartate receptor (NMDAR) antagonist^ 1 , has revolutionized the treatment of depression because of its potent, rapid and sustained antidepressant effects^ 2 – 4 ....