Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats
Psychopharmacology April 1, 2019 Katja Savolainen, Jouni Ihalainen, Aaro J. Jalkanen et al. 13 citations
Rationale Social withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e., there is a significant unmet medical need in the treatment of these symptoms. Objective We wanted to confirm whether selective adrenergic α_2C receptor (AR) antagonist therapy could ameliorate acute...