Crystal structure of an LSD-bound human serotonin receptor
Cell January 26, 2017 Daniel Wacker, Sheng Wang, John D. Mccorvy et al. 466 citations
SUMMARY The prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD’s key diethylamide moiety. LSD dissociates exceptionally slowly from both...