This study aimed to determine the rates, chronicity, and correlates of nightmares and insomnia, alone and in combination, in U.S. Army personnel at predeployment and postdeployment. Service members were assessed prior to (N = 3,952) and following (N = 1,762) a combat deployment between 2010 and 2016. Participants were categorized predeployment into nightmare and insomnia groups using the PTSD...
iScienceJanuary 16, 2026Amir Valizadeh, John D Roache, Xinyu Zhang et al.2 citations
Post-traumatic stress disorder (PTSD) exhibits extensive clinical and biological variability, making treatment challenging. The Consortium to Alleviate PTSD (CAP)-ketamine trial, the largest randomized study of ketamine for PTSD, found no overall benefit of ketamine over placebo, underscoring the necessity to identify responsive subgroups. Using pre-treatment blood DNA methylation profiles and...
This study tested the efficacy of repeated intravenous ketamine doses to reduce symptoms of posttraumatic stress disorder (PTSD). Veterans and service members with PTSD (n = 158) who failed previous antidepressant treatment were randomized to 8 infusions administered twice weekly of intravenous placebo (n = 54), low dose (0.2 mg/kg; n = 53) or standard dose (0.5 mg/kg; n = 51) ketamine....