Side-Chain Homologs of Δ9-THC, Δ8-THC, and HHC Reveal Pathway Bias at CB1R and CB2R Cannabinoid Receptors.
Molecular Neurobiology August 20, 2026 Oleh Durydivka, Ondřej Florián, Petr Palivec et al.
Minor cannabinoids and semisynthetic cannabis constituents, such as derivatives of tetrahydrocannabinol (THC) and hexahydrocannabinol (HHC), are increasingly encountered in consumer products, yet their signaling profiles at cannabinoid receptors remain incompletely characterized. Here, we describe how structural modifications of THC and HHC, including variations in alkyl side-chain length...
DOI: 10.1007/s12035-026-06145-8 (opens in new tab)
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Tetrahydrocannabinol
Arrestins
Cannabinoid receptors
G protein-coupled receptors
+2