Three women aged 27 to 34 reported distinct changes in menstrual function after using classic psychedelics: resumption of menses after amenorrhea, early onset of menses when psychedelics were used in the mid to late luteal phase, and improved menstrual regularity in a woman with irregular cycles later diagnosed with polycystic ovarian syndrome. The mechanisms remain unclear but may involve 5-HT2A receptor effects on the hypothalamic-pituitary-gonadal axis. These effects, largely overlooked in psychedelic research, may have therapeutic potential and need further investigation.
Among 346 LGBTQIA+ individuals, mostly White and in their early 30s, those who used psychedelics reported improvements in mental health and shifts in gender and sexual identity. Retrospective reports showed large reductions in traumatic stress, depression, and anxiety, along with increased psychological flexibility. A significant link emerged between the intensity of the psychedelic experience and greater self-acceptance and sexual identity exploration. Most participants (77%) saw therapeutic potential in psychedelics for gender dysphoria, and 65% reported changes in gender identity attitudes after use. The findings suggest psychedelics may support identity exploration and mental health in this population, warranting further research.