Multidimensional analysis of social withdrawal in the sub-chronic phencyclidine rat model for schizophrenia.
Psychopharmacology April 23, 2026 Stefani Kalli, Alina Davletova, Lenka Seillier et al.
RATIONALE: Social withdrawal in the sub-chronic phencyclidine (PCP) rat model—a behavioral correlate of schizophrenia’s negative symptoms—is well characterized, yet the psychological mechanisms underlying this deficit remain unclear. OBJECTIVES: Despite the complexity of social behavior, assessments often rely on a single metric (e.g., total interaction time) that has limited explanatory power,...