AbstractPsychedelic-assisted interventions are complex, context-sensitive interventions in which pharmacological, psychological, relational, environmental, cultural, and temporal processes interact. Trials of psilocybin and related compounds have reported promising but heterogeneous findings across psychiatric, substance-use, and existential indications, while also revealing challenges related...
Demoralization syndrome (DS) - a distinct clinical entity characterized by helplessness, hopelessness, and a persistent loss of meaning - affects approximately one in five Canadians with advanced cancer and is associated with increased desire for hastened death, negative clinical outcomes, and higher economic burden, yet recognition and treatment of DS remains suboptimal in modern oncology....