Serotonin releasers increase prepulse inhibition in serotonin 1B knockout mice.
Psychopharmacology April 1, 2000 S C Dulawa, K A Scearce-Levie, R Hen et al. 26 citations
Prepulse inhibition (PPI) is the normal reduction of the startle response which occurs when an abrupt startling stimulus is preceded by a weak pre-stimulus and is decreased in several neuropsychiatric disorders. The role of the serotonin 1B (5-HT(1B)) receptor in modulating PPI was investigated using 5-HT-releasing agents in wild-type (WT) and 5-HT1B knockout (1BKO) mice. Whether the...