Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues.
Journal of Medicinal Chemistry December 26, 2014 Andrew P Riley, Chad E Groer, David Young et al. 115 citations
The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for substance abuse. Although several successful semisynthetic studies have been performed to elucidate structure-activity relationships, the lack of analogues with substitutions to the furan ring of salvinorin...