Global excitatory synchrony: Ketamine induces global common-mode excitatory network oscillation by decoupling key interneurons.
bioRxiv : the preprint server for biology August 2, 2025 Belen Karakullukcu, Hamilton White, Christopher Connor et al. preprint
Ketamine is a dissociative anesthetic used in subanesthetic doses with analgesic and anti-depressive properties. However, its mechanistic effects on neuronal signaling and circuit function remain underexplored. We address this shortcoming by employing multi-neuronal imaging in the simple nematode C. elegans that allows measurement of neuron activity across the animal's entire head with...