Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors.
Proceedings of the National Academy of Sciences May 28, 2024 Elie Adam, Marek Kowalski, Oluwaseun Akeju et al. 30 citations
Ketamine is an N-methyl-D-aspartate (NMDA)-receptor antagonist that produces sedation, analgesia, and dissociation at low doses and profound unconsciousness with antinociception at high doses. At high and low doses, ketamine can generate gamma oscillations (>25 Hz) in the electroencephalogram (EEG). The gamma oscillations are interrupted by slow-delta oscillations (0.1 to 4 Hz) at high doses....
DOI: 10.1073/pnas.2402732121 (opens in new tab)
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Nmda-receptor antagonism
Antidepressant effect
Biophysical mechanisms
Gamma oscillations
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